I did my homes and shops in a neighborhood community style. I did not want my villagers spread out far from each other. I find it more lively this way to see them all as a close knit community. If I can get the picture downloaded later I will show them. Basically, in the center going bottom up. I have Nooks, then Sisters followed by a Community Spruce tree. Surrounded by cherry speakers and benches for an enjoyable relaxing time. Then around the shops are the house. A column of 3 houses on each side with a row of 4 at the top. Nice walk ways and will add more environmental decorations later. Oh and bamboo speakers behind every house. This uses up the negative space you normally don't see behind the house as well as prevents weeds and fossil spawns. Not to mention gives music all around.
I did this in a small area of the island. Leaving the Resident Center, Museum and Campsite on the largest portion where I am doing several sectioned off gardens. Like my 20x20 rainbow flower garden I just finished last night.
Along the top half of the map. I have player homes, a shrine hill with water falls, double tall waterfall leading down from high cliffs and a fruit tree orchard.
I designed all this to look nice but be more functional. It's not as glamorous as a lot of players or even natural. It is very man made looking, but I wanted it to be easy to do everything I wanted.
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Here is a museum design I though of doing but didn't you might like. The museum is tall. Blocking view behind it. So make it a Museum on a hill along the back side of your island. Build up a lv 3 high hill along the back of your island. Start with an area you size and spot you want the museum. Then build out the hill from there. If I remember correctly. The museum is 4x7. You can add nice water falls leading down with the ramps going up. Maybe dino's as you climb or monuments. Who knows. It gets rid of the negative space behind the museum and makes it stand out as a bigger fixture.