About the 45th person to say they don’t like anime in this thread. I’m beginning to think it’s not such an unpopular opinion. 
There’s plenty of anime that delves into topics where the characters aren’t in high school, you just have to look for it.
Few examples off the top of my head:
Cowboy Bebop, Black Lagoon, Fullmetal Alchemist Brotherhood, Made in Abyss, Trigun, Samurai Champloo, Gurren Lagann, Fire Force, Akame ga Kill, Hunter x Hunter, Tower of God, Demon Slayer, The Rising of The Shield Hero, One Punch Man, and Attack on Titan. In none of those are the characters being depicted as being in high school.
I said I wasn’t going to delve into the topic anymore, but I noticed you also mentioned anime not handling “adult” or “serious” themes well. Some of the shows I mentioned do actually do that, and there’s shows like Death Note, Death Parade, and Tokyo Ghoul that deal with issues such as psychological trauma and even death, shows which aren’t really intended for children. So to say anime doesn’t handle those issues isn’t even a matter of opinion anymore,,, it’s just factually incorrect.
Anyway, my unpopular opinion for today is that chicken with mayonnaise is delicious!

There’s plenty of anime that delves into topics where the characters aren’t in high school, you just have to look for it.
Few examples off the top of my head:
Cowboy Bebop, Black Lagoon, Fullmetal Alchemist Brotherhood, Made in Abyss, Trigun, Samurai Champloo, Gurren Lagann, Fire Force, Akame ga Kill, Hunter x Hunter, Tower of God, Demon Slayer, The Rising of The Shield Hero, One Punch Man, and Attack on Titan. In none of those are the characters being depicted as being in high school.
I said I wasn’t going to delve into the topic anymore, but I noticed you also mentioned anime not handling “adult” or “serious” themes well. Some of the shows I mentioned do actually do that, and there’s shows like Death Note, Death Parade, and Tokyo Ghoul that deal with issues such as psychological trauma and even death, shows which aren’t really intended for children. So to say anime doesn’t handle those issues isn’t even a matter of opinion anymore,,, it’s just factually incorrect.
Anyway, my unpopular opinion for today is that chicken with mayonnaise is delicious!
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