For me, in past towns, I've always made sure I had a town with a vertical slope on the south beach leading directly up to the door of Re-Tail. 2nd thing is I preferred a train coming from the left, but the right is fine if the other things matched up. Such as, having town square and town hall close to each other AND as far up to the north, by the train tracks, as possible. 1 or 2 ponds MAX. Then when they updated with the campgrounds, you make sure that was also as far up north as possible but the town hall and town square couldn't be too close to campgrounds. Town fruit of preference was peaches and pears. I was able to gave this "perfect" town by my standards at least 3 times.
My 2 currents, I've gotten lazy with spending literal DAYS even WEEKS until I found the most perfect town.
Ginger has a vertical slope on the south beach but it doesn't lead straight up to anything. But I do have Town hall AND Re-Tail lined up perfectly on the same row, close to the vertical slope, which I had thread a T-Intersection through, which I think actually looks super nice. 1 pond. And town tree is still north, and next to the train station, and a couple walks west is my campground. My town fruit is Cherries and although not my favorite, I initially was excited to have cherries as my town fruit, however, I got sick of looking at them so I don't have to many of them planted. Lots of other fruits though. To hide the fact my town fruit is cherries lol. Also my train comes from the left so it feels the most natural to me.
My new town, Citron, is a bit of a challenge for me. There's a vertical slope on the south beach that leads to nothing. Retail and Town Hall are lined up but opposite sides of the north of my map. Town Square is to the direct right of Town hall and campground next to that. Very closely packed. 1 pond as well. This town train station comes from the right. Town fruit is Oranges! I actually love the fact that it's Oranges and I got so lucky landing an okay town map with oranges because I wanted a town to fit my Citrus theme I'm trying to work on.
Thing is though, I found myself more often than not, hating or feeling dissatisfied with my previous towns because I lucked out so often and had perfect maps imo, that there was no challenges in putting them together. I ended up getting incredibly bored of them because it was essentially the same town but different themes, every time.
I adore my new towns have these differences or "quirks" in my eyes because it gives me more of an opportunity to become inspired and makw more unique layouts. I try not to stress too much about the layouts now. But I do still love the vertical south slope, minimal ponds and the neat alignments from my buildings. Other than that, anything is fine. I can make it work.