What is your favorite weapon?

[The Peanut Butter Fish]

Any type of one-handed blade is normally my favorite weapon from any game.

 

[n64king]

The Fat Man mini nuke launcher in Fallout 3 & New Vegas
Also using the Chainsaw or Rocket Launcher in Conker's BFD for N64 was always fun.

 

[00jachna]

- - - Post Merge - - -

These two <3

 

[MishMeesh]

For nostalgia/sentimental purposes: keyblade.

The one I most enjoy using in a game? Tough call. Maybe a bowgun from Monster Hunter.

 

[ThomasNLD]

I think its the massively upgraded sniper rifle from Resident Evil 4. I loved sniping in that game. I played so many games its hard to keep track though. That one came to mind first I suppose.
Also the good old AK47 from Goldeneye deserves a mention