I'm referring mostly to people that 'get in my way' on a daily basis so to speak. really everything from being stuck up idiots that think the world has to drop everything for them because they're rich/have power, to those that just don't do their jobs at all (ie store idiots I see practically THROWING lettuce onto the shelf like they're basketballs and then me getting to pick through that mess trying to find one that isn't going to go bad right away), to cashiers that take 500 years to count cash and/or come into work sneezing and coughing to handle non-bagged produce because they clearly want everyone else to get what they have, onto people that think the rest of the world has all the time in the world like them and drive like 15MPH below the speed limit when theres no one in front of them.
I could go on for hours and hours with this stuff.
as to the physical/mental other stuff, I've had chronic pain/health issues for half a decade, so yeah, every day has constant pain/suckage going on and worrying if it'll be my last on earth. its some pretty heavy stuff but when you've dealt with a health care system that does nowhere near enough to diagnosis you for 5 years you kinda lose hope :\
thats part of the reason I spend so much time here/animal crossing, they're distractions, albeit sometimes even they fail after awhile, as do other forms of self-care (what I can manage financially anyway, not that I get to eat well either due to being on disability and not having enough money for even food 3 times a day).