In Ruby, Kiki and Lolly seem to be the best of friends. I once found them walking on the beach together, and it was the cutest thing.
Also, Mira and Biskit are good friends, too. They're both neighbors, and Biskit gave Mira his shirt. lol
Inseperable duos in my towns:
Westerly: Avery and Bree, Elvis and Maelle
Granada: Becky and Lolly, Boone and Moe
New York: Beau and Kyle, Bluebear and Victoria, Butch and Caroline (like father and daughter)
Maple and Stitches in my town those two live quite near each other and they're best of friends. Feel sad for marshal as he was always best friends with her before Stitches came along.
Also Fang and Skye, they are always visiting each other and sending each other presents
Diana and Fuschia live right next to each other in my town and I always like to think that they're sisters since they have super different personalities
In my old town that I killed, Fang and Freya were basically a thing. I would see them sitting on benches together, always talking to each other, sharing shirts etc. But then at one point Fang called her his sister or something and ruined it for me