Best Pokemon Region Is -

[Slifer Slacker]

(title says it all) YOU DECIDE!

 

[Vex L'Cour]

Hoenn.

But Kanto was awesome during Pok?mon leaf green/fire red

 

[bittermeat]

Hoenn kept me playing the longest.

 

[easpa]

Hoenn. <3

 

[MasterC]

Sinnoh-Diamond version was my first Pokemon game.
Johto-The terrain and environment are awesome.

 

[KlopiTackle]

Kanto!

 

[Josh]

Hoenn, But the anime wasn't all that :/
My favourite Anime is Johto and Unova isn't too bad.

 

[Bacon Boy]

Hoenn