With X being the flower and O being an open space. And I try to having colors I know spawn hybrids colors I want touching, but that's pretty much it. I'm probably not very efficient with it lol. However, I have noticed I tend to get more hybrids when the weather is rainy, but that might just be personal luck, idk
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Oh, and roses for me are the most commonly spawned hybrids. But in one of my towns I had black tulips spread like a plague. I loved it, but I wish it had been another flower breed lol